International Textbook of Diabetes Mellitus PDF [4th Edition]

For nearly 20 years and three editions, the International Textbook of Diabetes Mellitus PDF has been a successful, well-respected medical textbook. The PDF, which is comprehensive and international in scope, covers all aspects of diabetes, ensuring a truly multidisciplinary and global approach. Diabetes epidemiology, diagnosis, pathogenesis, management, complications, and global public health issues are all covered.

It contains a wealth of new information on the scientific basis for and clinical management of this disease, with each new edition reflecting significant advancements in the field. Whereas other diabetes textbooks place a greater emphasis on clinical aspects and less on the basic science of diabetes, ITDM’s primary philosophy has always been to comprehensively cover the fundamental science of metabolism while closely connecting it to the pathophysiology and clinical aspects of the disease.

International Textbook of Diabetes Mellitus PDF is divided into 13 sections, each edited by a section editor of significant international prominence and edited by four world-famous diabetes specialists. This fourth edition includes two new areas on NAFLD, NASH, non-traditional associations with diabetes, and clinical trial evidence in diabetes. It covers all aspects of diabetes, from epidemiology and pathophysiology to management and complications.

This fourth edition of an international Textbook of Diabetes Mellitus PDF will once again provide the most comprehensive scientific reference book on diabetes to all those involved in diabetes research and development and diabetes specialists.

Preface of International Textbook of Diabetes Mellitus PDF

As the diabetes epidemic continues to grow in lockstep with the rapid spread of obesity, healthcare providers look for ways to reduce the morbidity, mortality, and rising costs associated with this debilitating disease that wreaks havoc on both the micro-and microvasculature. While the increase in type 2 diabetes incidence can be attributed to the population’s growing girth combined with a lack of physical activity, the marked increase in type 1 diabetes incidence remains unexplained.

Although our understanding of the cellular, biochemical, and molecular etiology of impaired insulin action and beta-cell failure has increased significantly, the genetic basis of type 1 and type 2 diabetes, as well as their associated complications, remains largely unknown. Despite introducing multiple new classes of antidiabetic agents for type 2 diabetes and more unique insulin preparations, insulin delivery systems, and glucose-sensing devices for type 1 diabetes, approximately half of all diabetic patients have suboptimal glycemic control increased risk of macrovascular complications is largely unexplained.

Many parts of the world lack access to these treatment advances, and instituting behavioral modification programs at the societal and individual levels is ineffective at halting the growing obesity epidemic. It remains to be seen whether the introduction of novel weight loss medications will help stem the tide of obesity.

The fourth edition [PDF] of the International Textbook of Diabetes Mellitus will remain the most widely referenced diabetes textbook globally, drawing on the expertise of leading basic scientists, clinicians, educators, and healthcare professionals from around the world to provide the most up-to-date information on diabetes research and clinical care.

This information will be a priceless resource, providing practicing physicians, basic scientists, and clinical investigators with the resources necessary to advance them to the frontiers of biomedical research in the fields of diabetes, metabolism, and obesity, as well as equipping them with state-of-the-art knowledge for optimizing clinical care for their diabetic patients.


Section I: Epidemiology
1 Classification of diabetes mellitus and other categories of glucose intolerance, 3
Dianna J. Magliano, Paul Zimmet and Jonathan E. Shaw
2 Epidemiology and risk factors for type 1 diabetes mellitus, 17
Andrea K. Steck and Marian J. Rewers
3 Epidemiology and geography of type 2 diabetes mellitus, 29
Qing Qiao, Desmond E. Williams, Giuseppina Imperatore, K.M. Venkat Narayan, and Jaakko Tuomilehto
Section II: Physiology of pancreatic function
4 Development and maintenance of the islet β cell, 55
Teresa L. Mastracci, Raghavendra G. Mirmira and Ryan M. Anderson
5 Pancreatic morphology in normal and diabetic states, 69
Rebecca L. Hull and Steven E. Kahn
6 Insulin gene expression and biosynthesis, 82
Vincent Poitout, Roland Stein and Christopher J. Rhodes
7 β-Cell biology of insulin secretion, 96
Susumu Seino, Tadao Shibasaki and Kohtaro Minami
8 Normal β-cell function, 108
Andrea Natali, Stefano Del Prato and Andrea Mari
9 Neuropeptides and islet hormone secretion, 125
Bo Ahrén
10 Biosynthesis, secretion, and action of glucagon, 136
Pierre J. Lefèbvre
11 Incretin physiology in health and disease, 145
Juris J. Meier and Michael A. Nauck
Section III: Normal physiology of insulin action
12 Mechanisms of insulin signal transduction, 163
Paul R. Langlais, Lawrence J. Mandarino and
W. Timothy Garvey
13 Regulation of glucose metabolism in the liver, 193
Shawn C. Burgess
14 Insulin actions in vivo: glucose metabolism, 211
Ele Ferrannini and Ralph A. DeFronzo
15 Measuring insulin action in vivo, 234
Richard N. Bergman and Marilyn Ader
16 Protein metabolism in health and diabetes, 250
Elena Volpi and Jared M. Dickinson
17 Lipid and lipoprotein metabolism, hypolipidemic
agents, and therapeutic goals, 262
Gissette Reyes-Soffer and Henry N. Ginsberg
18 Metabolomics: applications in type 2 diabetes mellitus and insulin resistance, 275
Sean H. Adams and John W. Newman
Section IV: NAFLD, NASH, and non-traditional associations with diabetes
19 Pathogenesis of nonalcoholic fatty liver disease (NAFLD), 283
Hannele Yki-Järvinen
20 Treatment of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), 292
Fernando Bril, Kwame Ntim, Romina Lomonaco and
Kenneth Cusi
21 Type 2 diabetes and cancer, 306
Emily Jane Gallagher, Ruslan Novosyadlyy, and Derek LeRoith
22 Diabetes and sleep apnea, 316
Abd A. Tehrani
viii Contents
Section V: Pathogenesis
23 The insulin resistance syndrome, 339
Naveed Sattar, Paul Welsh, and David Preiss
24 β-cell mass and function in human type 2 diabetes, 354
Piero Marchetti and Ele Ferrannini
25 Pathogenesis of type 2 diabetes mellitus, 371
Ralph A. DeFronzo
26 The genetics of type 2 diabetes, 401
Emma Ahlqvist and Leif Groop
27 Glucose toxicity, 413
Hannele Yki-Järvinen and Donald A. McClain
28 Monogenic disorders of the β cell, 426
Ali J. Chakera and Andrew T. Hattersley
29 Immunopathogenesis of type 1 diabetes in Western society, 442
Alberto Pugliese
30 Molecular genetics of type 1 diabetes, 454
M. Ann Kelly, Simon D. Rees, Anthony H. Barnett and
Stephen C. Bain
Section VI: Obesity
31 The relationship between obesity and type 2
diabetes— the role of gut factors, 469
Daniel S. Hsia and William T. Cefalu
32 The role of energy metabolism in the regulation of
energy balance, 479
Charmaine S. Tam and Eric Ravussin
33 Treatment of obesity: lifestyle and pharmacotherapy, 489
Arne Astrup
34 Treatment of obesity: bariatric surgery, 505
Karl J. Neff, Ele Ferrannini and Carel W. le Roux
35 Animal models of obesity and type 2 diabetes, 519
David A. York, Mie Jung Park-York and Timothy Gilbertson
36 The role of the hypothalamus in the maintenance of
energy balance and peripheral glucose control, 529
Luis Varela and Tamas L. Horvath
Section VII: Clinical trial evidence in diabetes
37 Prevention of type 1 diabetes, 541
Jay S. Skyler
38 Prevention of type 2 diabetes, 550
Thomas Yates and Melanie J. Davies
39 Prevention of diabetic microvascular complications, 564
Alice P.S. Kong and Juliana C.N. Chan
Section VIII: Management of diabetes: diet,
exercise and drugs
40 Dietary management of diabetes mellitus in Europe
and North America, 577
Jim I. Mann and Alexandra Chisholm
41 Exercise, 589
Henrik Galbo and Erik A. Richter
42 Sulfonylureas and meglitinides: insights into
physiology and translational clinical utility, 615
Harold E. Lebovitz and Arne Melander
43 Metformin and other biguanides: pharmacology and therapeutic usage, 641
Susan L. Samson and Alan J. Garber
44 PPAR agonists in the treatment of diabetes, 657
Sunder Mudaliar and Robert R. Henry
45 α-Glucosidase inhibitors, 673
Josée Leroux-Stewart, Rémi Rabasa-Lhoret and
Jean-Louis Chiasson
46 Combination therapy in type 2 diabetes mellitus, 686
Muhammad Abdul-Ghani, Ralph A. DeFronzo, and Roy Eldor
47 New drugs for the treatment of diabetes mellitus, 709
Clifford J. Bailey
48 Incretin-based therapies, 726
Michael A. Nauck and Juris J. Meier
49 Insulin pumps, 745
Dace L. Trence and Irl B. Hirsch
50 Innovative therapies in diabetes: colesevelam and
bromocriptine, 758
Shamsa Ali and Vivian Fonseca
Section IX: Management of diabetes:
monitoring and other interventions
51 Implantable pumps and artificial and bio-artificial
pancreas system, 767
William V. Tamborlane and Miladys M. Palau-Collazo
52 Pancreas and islet transplantation, 774
R. Paul Robertson
53 Hypoglycemia and other complications of insulin
therapy, 783
Stephanie A. Amiel
Contents ix
54 Diabetic ketoacidosis and hyperosmolar state, 799
Abbas E. Kitabchi, Guillermo E. Umpierrez and
Mary Beth Murphy
Section X: Management of diabetes:
glucose and lipid monitoring, specific subgroups
55 Type 2 diabetes in obese adolescents:
pathophysiology and treatment, 817
Grace Kim and Sonia Caprio
56 Diabetes in pregnancy, 823
Yoel Toledano, Eran Hadar and Moshe Hod
57 Aging and diabetes mellitus, 836
Hermes Florez, Jorge Ruiz, and Medha Munshi
58 Psychological problems and management of
patients with diabetes mellitus, 846
Alan M. Delamater, Ashley Marchante and Jennifer
59 Glycated hemoglobin, serum proteins, and other
markers as tools for monitoring, 853
Susan M. Gerber, Douglas F. Stickle, Intekhab Ahmed and Serge A. Jabbour
Section XI: Complications of diabetes:
general and microvasular
60 Pathogenesis of diabetic microvascular
complications, 875
Josephine M. Forbes and Brooke Harcourt
61 Diabetic retinopathy and other ocular complications, 889
Gavin S. Tan and Tien Yin Wong
62 Diabetic nephropathy, 911
George Jerums, Elif I. Ekinci, Erosha Premaratne, Scott
T. Baker, Sianna Panagiotopoulos and Richard J. MacIsaac
63 Pathology of human diabetic neuropathy, 926
M. Mojaddidi, A.K. Sharma and Rayaz A. Malik
64 Autonomic neuropathy, 939
Chinmay S. Marathe, Liza Phillips and Michael Horowitz
65 Connective tissue disorders in diabetes, 953
Arlan L. Rosenbloom
66 The diabetic foot, 964
Frank L. Bowling and Andrew J.M. Boulton
67 Erectile dysfunction in diabetes mellitus, 975
Michael H. Cummings and Rajesh Rajendran
68 Periodontal disease and diabetes mellitus, 988
Wenche S. Borgnakke and Robert J. Genco
Section XII: Complications of diabetes:
69 Epidemiology of macrovascular disease and
hypertension in diabetes mellitus, 1007
Jaakko Tuomilehto, Daiva Rastenyte, Qing Qiao,
Noël C. Barengo and Karl Matz
70 Atherogenesis, coronary heart disease and insulin
resistance syndrome in diabetes, 1031
Barak Zafrir and Jorge Plutzky
71 Endothelial function and metabolic syndrome, 1046
Xinpu Chen and Sridevi Devaraj
72 Hemostatic abnormalities in diabetes mellitus, 1051
R.A. Ajjan and Peter J. Grant
73 Clinical features and treatment of coronary heart
disease in diabetes, 1064
Eberhard Standl, Michael Erbach, Markolf Hanefeld,
Oliver Schnell, Bernd Stratmann and Diethelm Tschoepe
74 Arterial hypertension in diabetes: etiology and
treatment, 1079
Colleen Flynn and George Bakris
75 Peripheral vascular and cerebrovascular disease in
diabetes mellitus, 1091
Debabrata Mukherjee
Section XIII: Diabetes and public health
76 The diabetes challenge: from human and social
rights to the empowerment of people with diabetes, 1105
C.T. Di Iorio, Fabrizio Carinci and M. Massi Benedetti
77 The economics of diabetes care: a global
perspective, 1113
Rhys Willi

Book Details

  • Book Name: International Textbook of Diabetes Mellitus, 4th Edition
  • Authors: R. A. DeFronzo (Editor), E. Ferrannini (Editor), Paul Zimmet (Editor), George Alberti (Editor)
  • Publisher ‏: ‎ Wiley-Blackwell; 4th edition (May 18, 2015)
  • Language ‏: ‎ English
  • Hardcover ‏: ‎ 1240 pages
  • ISBN-10 ‏: ‎ 0470658614
  • ISBN-13 ‏: ‎ 978-0470658611
  • Item Weight ‏: ‎ 7.9 pounds
  • Dimensions ‏: ‎ 9.8 x 3.3 x 11.9 inches

Download PDF of the International Textbook of Diabetes Mellitus

For those who have financial problems and need the e-book or pdf version, we provide them the book’s copy totally free. And If the owner of the book gives a complaint about the pdf copy then we are bound to remove the copy from our site!
To file a complaint, email us–

Please don’t forget to comment if you couldn’t download this file or if you face any kind of issue! Or you can provide your email to the comment section, and we will send you the pdf copy through your email! And also, please must share your experience with this book. We will publish your comment though you add a relevant link about this content!

%d bloggers like this: