May 18, 2021

Goodman and Gilman’s the pharmacological basis of therapeutics pdf

Goodman and Gilman’s the pharmacological basis of therapeutics pdf, Thirteenth Edition represents the top of authority and accuracy in describing the actions and uses of therapeutic agents in reference to physiology and pathophysiology. Goodman and Gilman’s careful balance of fundamental science and clinical application has guided a great many experts and students to a straightforward comprehension of the drugs fundamental to diagnosing, preventing, and treating disease.


The Thirteenth Edition of Goodman and Gilman’s the pharmacological basis of therapeutics pdf includes quite 500 color illustrations, with many new figures emphasizing mechanisms of drug action. quite 30 new contributors have added to the present edition, while the main target on basic principles is undiminished.

This edition is enhanced by timely new content:

  • NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of hepatitis
  • Expanded coverage of disorder, with separate chapters on myocardial ischemia, hypertension, and coronary failure
  • Expanded emphasis on cellular flagging pathways engaged with drug activity
  • Summary tables at the top of every chapter that organize drugs discussed therein chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips
  • Chapter Content Outlines at the start of every chapter
  • Abbreviation boxes in every chapter to simply identify the abbreviations appearing therein chapter

More than a textbook, Goodman & Gilman’s maybe a working template for the effective and rational prescribing of medicine in daily practice.

To Download Goodman and Gilman’s the pharmacological basis of therapeutics pdf click bellow’s link

Preface of Goodman and Gilman’s the pharmacological basis of therapeutics pdf

The first edition of Goodman and Gilman’s the pharmacological basis of therapeutics pdf appeared in 1941, the product of a collaboration between two friends and professors at Yale, Louis Goodman, and Alfred Gilman. Their purpose, stated in the preface to that edition, was to correlate pharmacology with related medical sciences, to reinterpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the applications of pharmacodynamics to therapeutics, and to create a book that would be useful to students of pharmacology and to physicians. We continue to follow these principles in the 13th edition.

The 1st edition was quite successful despite its high price, $12.50, and soon became known as the “blue bible of pharmacology.” The book was evidence of the deep friendship between its authors, and when the Gilmans’ son was born in 1941, he was named Alfred Goodman Gilman. World War II and the relocation of both authors—Goodman to Utah, Gilman to Columbia—postponed a second edition until 1955. The experience of writing the second edition during a period of accelerating basic research and drug development persuaded the authors to become editors, relying on experts whose scholarship they trusted to contribute individual chapters, a pattern that has been followed ever since.

Alfred G. Gilman, the son, served as an associate editor for the 5th edition (1975), became the principal editor for the 6th (1980), 7th (1985), and 8th (1990) editions, and consulting editor for the 9th and 10th editions that were edited by Lee Limbird and Joel Hardman. After an absence in the 11th edition, Al Gilman agreed to co-author the introductory chapter in the 12th edition. His final contribution to G&G, a revision of that chapter, is the first chapter in this edition, which we dedicate to his memory.

A multi-authored text of this sort grows by accretion, posing challenges to editors but also offering 75 years of wisdom, memorable pearls, and flashes of wit. Portions of prior editions persist in the current edition, and we have given credit to recent former contributors at the end of each chapter. Such a text also tends to grow in length with each edition, as contributors add to the existing text and as pharmacotherapy advances. To keep the length manageable and in a single volume, Dr. Randa Hilal-Dandan and I prepared a shortened version of each chapter and then invited contributors to add back old material that was essential and to add new material.

We also elected to discard the use of extract (very small) type and to use more figures to explain signaling pathways and mechanisms of drug action. Not wanting to favor one company’s preparation of an agent over that of another, we have ceased to use trade names except as needed to refer to drug combinations or to distinguish multiple formulations of the same agent with distinctive pharmacokinetic or pharmacodynamics properties. Counter-balancing this shortening is five new chapters that reflect advances in the therapeutic manipulation of the immune system, the treatment of viral hepatitis, and the pharmacotherapy of cardiovascular disease and pulmonary artery hypertension.

Editing such a book brings into view a number of overarching issues: Over-prescribing of antibiotics and their excessive use in agricultural animal husbandry continues to promote the development of antimicrobial resistance; the application of CRISPR/cas9 will likely provide new therapeutic avenues; global warming and the sheer size of the human population require medical scientists and practitioners to promote remedial and preventive action based on data, not ideology.

A number of people have made invaluable contributions to the preparation of this edition. My thanks to Randa Hilal-Dandan and Bjorn Knollmann for their editorial work; to Harriet Lebowitz of McGraw-Hill, who guided our work, prescribed the updated style, and kept the project moving to completion; to Vastavikta Sharma of Cenveo Publishers Services, who oversaw the copy editing, typesetting, and preparation of the artwork; to Nelda Murri, our consulting pharmacist, whose familiarity with the clinical pharmacy is evident throughout the book; to James Shanahan, publisher at McGraw-Hill, for supporting the project; and to the many readers who have written to critique the book and offer suggestions.

Contents of Goodman and Gilman’s the pharmacological basis of therapeutics pdf

Section I

General Principles 1

1. Drug Invention and the Pharmaceutical Industry

Suzanne M. Rivera and Alfred Goodman Gilman

2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination

Iain L. O. Buxton

3. Pharmacodynamics: Molecular Mechanisms of Drug Action

Donald K. Blumenthal

4. Drug Toxicity and Poisoning

Michelle A. Erickson and Trevor M. Penning

5. Membrane Transporters and Drug Response

Kathleen M. Giacomini and Yuichi Sugiyama

6. Drug Metabolism

Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey

7. Pharmacogenetics

Dan M. Roden

Section II

Neuropharmacology 113

8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems

Thomas C. Westfall, Heather Macarthur, and David P. Westfall

9. Muscarinic Receptor Agonists and Antagonists

Joan Heller Brown, Katharina Brandl, and Jürgen Wess

10. Anticholinesterase Agents

Palmer Taylor

11. Nicotine and Agents Acting at the Neuromuscular Junction and Autonomic Ganglia

Ryan E. Hibbs and Alexander C. Zambon

12. Adrenergic Agonists and Antagonists

Thomas C. Westfall, Heather Macarthur, and David P. Westfall

13. 5-Hydroxytryptamine (Serotonin) and Dopamine

David R. Sibley, Lisa A. Hazelwood, and Susan G. Amara

14. Neurotransmission in the Central Nervous System

R. Benjamin Free, Janet Clark, Susan Amara, and David R. Sibley

15. Drug Therapy of Depression and Anxiety Disorders

James M. O’Donnell, Robert R. Bies, and Richard C. Shelton

16. Pharmacotherapy of Psychosis and Mania

Jonathan M. Meyer

17. Pharmacotherapy of the Epilepsies

Misty D. Smith, Cameron S. Metcalf, and Karen S. Wilcox

18. Treatment of Central Nervous System Degenerative Disorders

Erik D. Roberson

19. Hypnotics and Sedatives

S. John Mihic, Jody Mayfield, and R. Adron Harris

20. Opioids, Analgesia, and Pain Management

Tony Yaksh and Mark Wallace

21. General Anesthetics and Therapeutic Gases

Hemal H. Patel, Matthew L. Pearn, Piyush M. Patel, and David M. Roth

22. Local Anesthetics

William A. Catterall and Kenneth Mackie

23. Ethanol

S. John Mihic, George F. Koob, Jody Mayfield,

and R. Adron Harris

24. Drug Use Disorders and Addiction

Charles P. O’Brien

Section III

Modulation of Pulmonary, Renal, and

Cardiovascular Function 443

25. Drugs Affecting Renal Excretory Function

Edwin K. Jackson

26. Renin and Angiotensin

Randa Hilal-Dandan

27. Treatment of Ischemic Heart Disease

Thomas Eschenhagen

28. Treatment of Hypertension

Thomas Eschenhagen

29. Therapy of Heart Failure

Thomas Eschenhagen

30. Antiarrhythmic Drugs

Bjorn C. Knollmann and Dan M. Roden

31. Treatment of Pulmonary Arterial Hypertension

Dustin R. Fraidenburg, Ankit A. Desai, and Jason X.-J. Yuan

32. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs

Kerstin Hogg and Jeffrey I. Weitz

33. Drug Therapy for Dyslipidemias

Holly E. Gurgle and Donald K. Blumenthal

Section IV

Inflammation, Immunomodulation, and Hematopoiesis 619

34. Introduction to Immunity and Inflammation

Nancy Fares-Frederickson and Michael David

35. Immunosuppressants and Tolerogens

Alan M. Krensky, Jamil R. Azzi, and David A. Hafler

36. Immune Globulins and Vaccines

Roberto Tinoco and James E. Crowe, Jr.

37. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor

Emer M. Smyth, Tilo Grosser, and Garret A. FitzGerald

38. Pharmacotherapy of Inflammation, Fever, Pain, and Gout

Tilo Grosser, Emer M. Smyth, and Garret A. FitzGerald

39. Histamine, Bradykinin, and Their Antagonists

Randal A. Skidgel

40. Pulmonary Pharmacology

Peter J. Barnes

41. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins

Kenneth Kaushansky and Thomas J. Kipps

Section V

Hormones and Hormone Antagonists 769

42. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis

Mark E. Molitch and Bernard P. Schimmer

43. Thyroid and Antithyroid Drugs

Gregory A. Brent and Ronald J. Koenig

44. Estrogens, Progestins, and the Female Reproductive Tract

Ellis R. Levin, Wendy S. Vitek, and Stephen R. Hammes

45. Androgens and the Male Reproductive Tract

Peter J. Snyder

46. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex

Bernard P. Schimmer and John W. Funder

47. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia

Alvin C. Powers and David D’Alessio

48. Agents Affecting Mineral Ion Homeostasis and Bone Turnover

Thomas D. Nolin and Peter A. Friedman

Section VI

Gastrointestinal Pharmacology 907

49. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastro esophageal Reflux Disease

Keith A. Sharkey and Wallace K. MacNaughton

50. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease

Keith A. Sharkey and Wallace K. MacNaughton

51. Pharmacotherapy of Inflammatory Bowel Disease

Wallace K. MacNaughton and Keith A. Sharkey

Section VII

Chemotherapy of Infectious Diseases 955

52. General Principles of Antimicrobial Therapy

Tawanda Gumbo

53. Chemotherapy of Malaria

Joseph M. Vinetz

54. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis,

Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections

Dawn M. Wetzel and Margaret A. Phillips

55. Chemotherapy of Helminth Infections

Jennifer Keiser, James McCarthy, and Peter Hotez

56. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections

Conan MacDougall

57. Penicillins, Cephalosporins, and Other β-Lactam Antibiotics

Conan MacDougall

58. Aminoglycosides

Conan MacDougall

59. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents

Conan MacDougall

60. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy

Tawanda Gumbo

61. Antifungal Agents

P. David Rogers and Damian J. Krysan

62. Antiviral Agents (Nonretroviral)

Edward P. Acosta

63. Treatment of Viral Hepatitis (HBV/HCV)

Jennifer J. Kiser and Charles W. Flexner

64. Antiretroviral Agents and Treatment of HIV Infection

Charles W. Flexner

Section VIII

Pharmacotherapy of Neoplastic Disease 1159

65. General Principles in the Pharmacotherapy of Cancer

Anton Wellstein

66. Cytotoxic Drugs

Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville

67. Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules

Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins,

and Edward A. Sausville

68. Hormones and Related Agents in the Therapy of Cancer

Claudine Isaacs, Anton Wellstein, and Anna T. Riegel

Section IX

Special Systems Pharmacology 1249

69. Ocular Pharmacology

Jeffrey D. Henderer and Christopher J. Rapuano

70. Dermatological Pharmacology

Matthew J. Sewell, Craig N. Burkhart, and Dean S. Morrell

71. Environmental Toxicology: Carcinogens and Heavy Metals

Michael C. Byrns and Trevor M. Penning

Appendices

I. Principles of Prescription Order Writing and Patient Compliance

Iain L. O. Buxton

II. Design and Optimization of Dosage Regimens:

Pharmacokinetic Data

Kenneth E. Thummel, Danny D. Shen, and Nina Isoherranen

Authors

Alfred Goodman Gilman

Editor-in-chief
Laurence L. Brunton, PhD
Professor of Pharmacology and Medicine
School of Medicine, University of California, San Diego
La Jolla, California



Editors

Lecturer in Pharmacology
School of Medicine, University of California, San Diego
La Jolla, California


Björn C. Knollmann, MD, PhD
William Stokes Professor of Medicine and Pharmacology
Director, Vanderbilt Center for Arrhythmia Research and Therapeutics
Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Nashville, Tennessee
New

Product details

  • Publisher : McGraw-Hill Education / Medical; 13th edition (December 5, 2017)
  • Authors: Laurence L. Brunton, PhD & Randa Hilal-Dandan, PhD & Björn C. Knollmann, MD, PhD
  • Language: English
  • Hardcover: 1440 pages
  • ISBN-10: 1259584739
  • ISBN-13: 978-1259584732
  • Item Weight: 6.93 pounds
  • Dimensions: 8.7 x 2.2 x 11.1 inches
  • Best Sellers Rank: #96,955 in Books

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Best Reviews

This classic textbook is thorough and covers all the topics well. It is still one of the bibles of medicine and very useful to all health professionals for that matter.

Phil G.

The 8 chapters I’ve read were comprehensive but concise.


Neil

I'm a physician and author. This is a definitive text and where I go when I need quick and authoritative answers. Easy to use, thorough, and readable. You can't ask for better.

JM Harley

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