May 18, 2021

Anesthetic Pharmacology Basic Principles and Clinical Practice pdf

Anesthetic Pharmacology Basic Principles and Clinical Practice pdf are based on pharmacological anesthesia which can be determined by name. Lately, our comprehension of sub-atomic instruments of medication activity and inter-individual fluctuation in medication reaction has developed hugely. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and various locations outside the OR.

Anesthetic Pharmacology: Basic Principles and Clinical Practice, second edition, is an impressive therapeutic resource in anesthesia and important care: Section 1 introduces the principles of drug action, the new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and therefore the application of medicine in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from a world team of experts, and illustrated full color, this is often a classy, user-friendly resource for all practitioners providing care within the perioperative period. Section 2 presents the atomic, cell, and coordinated physiology of the objective organ/utilitarian framework, and Section 3 audits the pharmacology and toxicology of sedative medications.

  1. Thorough: covers all the key pharmacologic and physiologic data on how each medication functions at an atomic, cell, and organ level.
  2. Useful: gives all the significant medication data an anesthetist requires – portion ranges, collaborations with different medications, poisonousness, and use in various patient gatherings.
  3. Applicable: the new segment on Therapeutics of Clinical Practice advises the anesthetist on how to choose and utilize the correct medications in a wide scope of everyday clinical situations.

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Preface of Anesthetic Pharmacology Basic Principles and Clinical Practice pdf

Recent years have seen the beginning of a revolution in our understanding of how anesthesia is produced and how the drugs used by perioperative practitioners work at a molecular level. Concomitantly, the clinical practice of anesthesia has become increasingly more complex and demanding. As a result of these developments, there continues to be a growing chasm between clinically sophisticated anesthesiologists who may be inadequately versed in basic and molecular pharmacology, and anesthetic researchers who are well versed in the mechanistic details of anesthetic drug action but inadequately informed about the clinical context in which these drugs are used. The first edition of Anesthetic Pharmacology: Physiologic Principles and Clinical Practice were assembled with the aim of bridging this chasm. Since then, the understanding of molecular mechanisms of drug action has grown, mechanisms of inter-individual variability in drug response are better understood, and the practice of anesthesiology has expanded to the preoperative environment, locations out of the operating room and out of the hospital, and into various intensive care units. Consequently, Anesthetic Pharmacology has been significantly revised into a second edition. Significant changes include the addition of a third editor, expansion from three to four sections, and enhanced organization and readability to make the material accessible to a wide range of trainees, practitioners, and pharmacologists. Anesthetic Pharmacology is designed to be a sophisticated, accessible, reliable, and user-friendly primer of fundamental and applied pharmacology that is targeted for use by the full spectrum of those providing care in the perioperative period.

The book is organized into four fully integrated sections. The first two sections consider the principles and targets of anesthetic drug action, and the last two sections address the pharmacology and therapeutic use of the drugs themselves. Section one, “Principles of drug action,” provides detailed theoretical and practical information about anesthetic pharmacokinetics and about cell signaling pathways involved in anesthetic drug action. Section two, “Physiologic substrates of drug action,” is conveniently arranged by organ systems and presents the molecular, cellular, and integrated physiology of the organ or functional system, highlighting targets and substrates. Section three, “Essential drugs in anesthetic practice,” presents the pharmacology and toxicology of major classes of drugs that are used preoperatively. A fourth section, “Clinical applications: evidence-based anesthesia practice,” has been added to this edition to provide integrated and comparative pharmacology and the practical therapeutic application of drugs for specific perioperative indications. The layout of the chapters accommodates the varying needs of the readership. Each chapter contains the fundamental body of knowledge needed by practitioners, as well as more in-depth information, including basic research directions and sophisticated clinical applications. The chapters all conclude with a concise summary of the material deemed to be essential knowledge for trainees and those seeking recertification. Through the judicious use of illustrations, boxes, and tables, information is presented in a comprehensible fashion for all levels of readership.

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Contents Anesthetic Pharmacology Basic Principles and Clinical Practice pdf

Section 1 Principles of drug action

1 Pharmacodynamic principles of drug action

Stuart A. Forman

2 G-protein-coupled receptors

Marcel E. Durieux

3 Ion channels

Thomas McDowell, Misha Perouansky, and

Robert A. Pearce

4 Other signaling pathways

Istvan Nagy, Isobel Lever, and Mario Cibelli

5 Principles of pharmacokinetics

Thomas W. Schnider and Charles F. Minto

6 Principles of drug biotransformation

Evan D. Kharasch

7 Drug transport and transporters

Roland J. Bainton and Evan D. Kharasch

8 Target-controlled infusions and closed-loop administration

Michel M. R. F. Struys and Tom De Smet

9 Alternative routes of drug administration

Ola Dale

10 Principles of pharmacogenetics

Kirk Hogan

11 Pharmacodynamic drug interactions in anesthesia

Talmage D. Egan and Charles F. Minto

12 Pharmacoeconomics

Alex Macario

Section 2 Physiologic substrates of drug action

13 Sleep and consciousness

George A. Mashour and Max Kelz

14 Synaptic transmission

M. B. MacIver

15 Memory, learning, and cognition

Robert A. Veselis

16 Mechanisms of pain transmission and transduction

Robert W. Gereau IV and Laura F. Cavallone

17 The generation and propagation of action potentials

Gary R. Strichartz

18 Neuromuscular function

Joe Henry Steinbach and Ling-Gang Wu

19 Vascular reactivity

Isao Tsuneyoshi, Josephine M. Garcia-Ferrer,

Hung Pin Liu, and Walter A. Boyle

20 Cardiac rhythm

Brian S. Donahue and Jeffrey R. Balser

21 Myocardial performance

Pierre Foëx and Helen Higham

22 Autonomic function

Jonathan Moss and David Glick

23 Immunity and inflammation

Nigel R. Webster and Helen F. Galley

Section 3 Essential drugs in anesthetic practice

24 Mechanisms of anesthetic action

C. Michael Crowder and Alex S. Evers

25 Pharmacokinetics of inhaled anesthetics

Geoff Lockwood

26 Clinical pharmacology of inhaled anesthetics

Thomas J. Ebert and Larry Linden baum

27 Pharmacokinetics of intravenous anesthetics

Frédérique S. Servin and John W. Sear

28 Clinical pharmacology of intravenous anesthetics

John W. Sear

29 Benzodiazepines

Uwe Rudolph, M. Frances Davies, and Juliana Barr

30 Alpha2-agonists and other sedatives and amnestics

Robert D. Sanders and Mervyn Maze

31 Mechanisms of action of opioids

Michael Schäfer

32 Pharmacokinetics of opioids

Dhanesh K. Gupta, Tom C. Krejcie, and Michael J. Avram

33 Clinical pharmacology of opioids

Carl E. Rosow and Mark Dershwitz

34 Nonsteroidal anti-inflammatory drugs

Nilesh Randive and Richard M. Langford

35 Other ion-channel and receptor ligands for analgesia

Mark A. Schumacher and Helge Eilers

36 Local anesthetics

Francis V. Salinas and David B. Auyong

37 Antiepileptic and antipsychotic drugs

W. Andrew Kofke

38 Neuromuscular blocking drugs

Heidrun Fink, Manfred Blobner, and J. A. Jeevendra Martyn

39 Drugs for reversal of neuromuscular blockade

Mohamed Naguib

40 Sympathomimetic and sympatholytic drugs

David F. Stowe and Thomas J. Ebert

41 Parasympathomimetic and parasympatholytic drugs

Berend Mets and Imre Redai

42 Beta-blockers and other adrenoceptor antagonists

Andrew J. Patterson

43 Antiarrhythmic drugs

Aman Mahajan and Charles W. Hogue Jr.

44 Positive inotropic drugs

Paul S. Pagel and David C. Warltier

45 Vasodilators

Roger A. Johns and Stephen Yang

46 Calcium channel blockers

W. Scott Beattie

47 Bronchodilators

Charles W. Emala

48 Pulmonary vasodilators

Sunita Sastry and Ronald G. Pearl

49 Renal protection and pharmacology

Dean R. Jones and H. T. Lee

50 Fluids and electrolytes

Robert G. Hahn

51 Corticosteroids and anti-inflammatory drugs

Clifford S. Deutschman

52 Antirejection drugs and immunosuppressants

Nándor Marczin and Kristof Racz

53 Antimotility and antisecretory drugs

Robert P. Walt and Eugene B. Campbell

54 Antiemetics

Jens Scholz, Markus Steinfath, and Patrick Meybohm

55 Insulin and antihyperglycemic drugs

Nick Oliver, Martin Smith, and Stephen Robinson

56 Nutritional pharmacology

Paul Wischmeyer

57 Drugs affecting coagulation and platelet function

Troy Wildes, Michael Avidan, and George Despotis

58 Obstetric pharmacology

Tony Gin

59 Antimicrobial therapy

Conan MacDougall, B. Joseph Guglielmo, and Jeanine Wiener-Kronish

Section 4 Clinical applications: evidence based anesthesia practice

60 Preoperative drug management

Laureen Hill

61 Induction of anesthesia

T. Andrew Bowdle

62 Maintenance of and emergence from anesthesia

J. Lance Lichtor

63 Management of sedation, analgesia, and delirium

Christopher G. Hughes, Stuart McGrane, E. Wesley Ely, and Pratik P. Pandaharipande

64 Postoperative analgesia

Richard W. Rosenquist and Ellen W. King

65 Control of blood pressure and vascular tone

Arthur Wallace

66 Cardiac protection and pharmacologic management of myocardial ischemia

Eric Jacobsohn, Waiel Almoustadi, and Chinniampalayam Rajamohan

67 Management of patients with chronic alcohol or drug use

Howard B. Gutstein

68 Drug allergy and treatment

Jerrold H. Levy

69 Pediatric pharmacology

Greg B. Hammer and Brian J. Anderson

70 Geriatric pharmacology

Jeffrey H. Silverstein

71 Emerging concepts of anesthetic neuroprotection and neurotoxicity

Brian P. Head and Piyush Patel


Alex S. Evers is Henry E. Mallinckrodt Professor of Anesthesiology, and Professor of Internal Medicine and Molecular Biology and Pharmacology, Washington University School of Medicine, USA. Professor Mervyn Maze is Chair, Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA.

Evan Kharasch is Russell D. and Mary B. Shelden Professor of Anesthesiology, Director, Division of Clinical and Translational Research, Department of Anesthesiology, and Professor of Biochemistry and Molecular Biophysics, Washington University, USA.

Product details

Book name: Anesthetic Pharmacology Basic Principles and Clinical Practice

Publisher: Cambridge University Press; 2nd edition (April 25, 2011)

Language: English

Hardcover: 1262 pages

ISBN-10: 0521896665

ISBN-13: 978-0521896665

Item Weight: 9.92 pounds

Best Sellers Rank: #1,010,257 in Books

Amazon Price: 152.59$

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